Tue, September 24
Tuesday, September 24, 2019 - Workshops
- Metals in Structural Biology
- Materials Science X-ray Diffraction Opportunities
- Ultrafast Electron Diffraction (UED)
- Satellite Event: Falling Walls Stanford (Kavli Auditorium)
Metals in protein environments can confer unique reactivity, and challenging chemistry often involves complex metallocofactors. Synchrotron-based techniques enable experiments that closely measure and monitor metal active site geometry and protein structure. For redox-active crystal samples on which X-ray diffraction data is obtained, parallel spectroscopic methods are being increasingly used to investigate whether the observed 3-dimensional structure is in an enzymatically active or inactive state, as well as whether the metal oxidation state has been altered in the X-ray beam. In this workshop on Metals in Structural Biology we will emphasize the use of spectroscopic methods and crystallography to study metalloenzyme structure and function.
- Location: Panofsky Auditorium, Building 053/Room 1320
- Organizers: Sarah Bowman (HWI), Aina Cohen (SLAC/SSRL), Jennifer Wierman (SLAC/SSRL)
- Panelists:
Graham George (U Saskatchewan)Tom Poulos (UC Irvine)Sarah Bowman (HWI)Jennifer Bridwell-Rabb (U Michigan)
- Program:
| Time | Topic | Speaker | Institution |
| 9:00 AM | Introduction | ||
| 9:10 AM | XAS: A Utility Tool Everyone Should Have in their Science Toolbox | Tim Stemmler | Wayne State University |
| 9:40 AM | Unraveling Complex Protein Allostery with Small-Angle X-ray Scattering | Nozomi Ando | Cornell University |
| 10:10 AM | Femtosecond X-ray Absorption Reveals Excited State Structural Dynamics in B12 Cofactors | Roseanne Sension | University of Michigan |
| 10:40 AM | Break (Group Photo-meet in front of SUSB) | ||
| 11:00 AM | Metallocluster Plasticity and Assembly in Carbon Monoxide Dehydrogenase | Elizabeth Wittenborn | University of California Berkeley |
| 11:30 AM | Structural Characterization of Nitrogenase then and now | Ailiena Maggiolo | Caltech |
| 12:00 PM | Lunch and panel | ||
| 1:30 PM | Kelly Chacon | Reed College | |
| 2:00 PM | Artificial Metalloprotein Assemblies and Materials | Akif Tezcan | Universit of California San Diego |
| 2:30 PM | Direct Detection of Protons in Oxidized and Reduced Human Manganese Superoxide Dismutase | Gloria Borgstahl | University of Nebraska Medical Center |
| 3:00 PM | Break | ||
| 3:30 PM | Fixed Target Serial Crystallography at Diamond Light Source | Graeme Winter | Diamond Light Source |
| 4:00 PM | Geometric and Electronic Structure of Organometallic Intermediates in Acetyl CoA Synthase | Riti Sarangi | SLAC/SSRL |
| 4:30 PM | Wrap-up |
Materials Science X-ray Diffraction Opportunites
There are exciting things happening for the SSRL scattering beamlines. We are in the process of building a new undulator beamline, BL17-2, to provide world-class scattering capabilities which will replace the science program at BL7-2. This new beam line, which should be ready for users a year from now, will have a 6 circle (psi C) diffractometer, analyzers and several 2D detectors, including a Eiger 4M and Eiger 2 500K. BL17-2 will have a focus spot of sub 20 microns in both directions with > 1 10^12 photons with the high resolution detector and 10^13 with a multilayer. We are organizing this workshop to explore various scientific applications that such a new beamline could enable. We look forward to sharing the design plans of this new beamline and discussing the new science that this will enable for our users.
- Location: Trinity Conference Room, Building 053/Room 1350
- Organizers: Apurva Mehta, Kevin Stone (SLAC/SSRL)
- Invited Speakers:
- Gaurav (Gino) Giri, U Virginia
- Joanne Stubbs, U Chicago
- Stephen Wilson, UCSB
- Badri Shyam, University of Dayton Research Institute
- Program:
| Time | Speaker | Topic | Institution |
| 9:00 AM | Michael Toney | BL17 Characteristics and Overview | SLAC |
| 9:30 AM | Joanne Stubbs | TBD | Univ. of Chicago |
| 10:00 AM | Yayoi Takamura | TBD | UC Davis |
| 10:30 AM | Break (Group Photo-meet in front of SUSB) | ||
| 11:00 AM | Guarav Giri | TBD | Univ. of Virginia |
| 11:30 AM | Stephen Wilson | TBD | UC Santa Barbara |
| 12:00 PM | Lunch | ||
| 1:30 PM | Badri Shyam | TBD | Univ. of Dayton Research Institute |
| 2:00 PM | Hans-Georg Steinrük | TBD | SLAC |
| 2:30 PM | Break | ||
| 2:50 PM | Diana Gamzina | TBD | SLAC |
| 3:20 PM | Kevin Stone | Beamline Commissioning Timeline | SLAC |
| 3:45 PM | Panel discussion/Q&A with beamline scientists | ||
| 4:30 PM | Adjourn |
Ultrafast Electron Diffraction (UED) Workshop
The UED workshop will discuss developments in UED science and related ultrafast techniques. It will be an opertunity to discuss the latest developments in ultrafast material and chemical sciences, solicit feedback about the first UED user run, and inform future developements of the SLAC MeV UED instrument.
- Location: ROB Conference Rooms A/B/C/D, Building 48
- Lead Organizer: Alex Reid
- Organizers: Jie Yang, Xiaozhe Shen, Ming-Fu Lin, Michael Kozina
- Abstract: Ultrafast MeV Electron Diffraction is a powerful tool for exploring material and chemical dynamics at Angstrom lengthscales and femtosecond time scale. The SLAC MeV UED instrument offered its first open call for user experiments in January 2019. This workshop will focus on major questions in ultrafast science, and how time-resolved MeV UED can be an effective tool towards answers. The worshop will cover both material science (with emphasis on quantum materials) and gas/liquid-phase chemistry.
- Program:
| Time | Title of Talk | Speaker | Institution |
| Session Chair: Alex Reid (SLAC) | |||
| 1:00 PM | UED Solid State Update | Xiaozhe Shen | SLAC |
| 1:15 PM | Time Resolved Probing of Photo-induced Phase Transitions in Charge Density Waves | Nuh Gedik | Massachusetts Institute of Technology |
| 1:40 PM | TBD | Mingda Li | Massachusetts Institute of Technology |
| 2:05 PM | Time-resolved probes of hydrodynamic behavior in quantum materials | Matteo Mitrano | University of Illinois at Urbana–Champaign |
| 2:30 PM | Break | ||
| Session Chair: Jie Yang (SLAC) | |||
| 3:00 PM | UED Gas Phase Update | Ming-Fu Lin | SLAC |
| 3:15 PM | Comparing structural and spectroscopic probes of excited state molecular dynamics: Relativistic ultrafast electron diffraction vs Time resolved photoelectron spectroscopy. | Thomas Weinacht | Stony Brook University |
| 3:40 PM | Excited States Structure Determination with X-rays and Electrons | Peter Weber | Brown University |
| 4:05 PM | Liquid Phase MeV-UED: Commissioning and First Results. | Kathryn Ledbetter | Stanford University |
| 4:30 PM | Conclusion of Workshop |
SLAC, Stanford and X The Moonshot Factory announce the 2019 Falling Walls Lab Stanford to be held at SLAC’s Kavli Auditorium in Building 51 on Tuesday, September 24, 3-5 pm. At this fun competition and networking event, you can pitch your great new idea or watch the competitors pitch theirs. Anyone within 10 years of Bachelors, 7 years of Masters or 5 years of PhD is eligible to compete. The winner will receive a trip to the final on November 9 in Berlin. To learn more or apply, visit https://falling-walls.com/lab/apply