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Tue, September 24

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Tuesday, September 24, 2019 - Workshops

Metals in Structural Biology 

Metals in protein environments can confer unique reactivity, and challenging chemistry often involves complex metallocofactors. Synchrotron-based techniques enable experiments that closely measure and monitor metal active site geometry and protein structure.  For redox-active crystal samples on which X-ray diffraction data is obtained, parallel spectroscopic methods are being increasingly used to investigate whether the observed 3-dimensional structure is in an enzymatically active or inactive state, as well as whether the metal oxidation state has been altered in the X-ray beam. In this workshop on Metals in Structural Biology we will emphasize the use of spectroscopic methods and crystallography to study metalloenzyme structure and function.

Graham George (U Saskatchewan)Tom Poulos (UC Irvine)Sarah Bowman (HWI)Jennifer Bridwell-Rabb (U Michigan)

  • Program:
TimeTopicSpeakerInstitution
9:00 AMIntroduction  
9:10 AMXAS: A Utility Tool Everyone Should Have in their Science ToolboxTim Stemmler Wayne State University
9:40 AMUnraveling Complex Protein Allostery with Small-Angle X-ray ScatteringNozomi Ando Cornell University
10:10 AMFemtosecond X-ray Absorption Reveals Excited State Structural Dynamics in B12 CofactorsRoseanne SensionUniversity of Michigan
10:40 AMBreak (Group Photo-meet in front of SUSB)  
11:00 AMMetallocluster Plasticity and Assembly in Carbon Monoxide DehydrogenaseElizabeth Wittenborn University of California Berkeley
11:30 AMStructural Characterization of Nitrogenase then and nowAiliena Maggiolo Caltech
12:00 PMLunch and panel  
1:30 PM Kelly Chacon Reed College
2:00 PMArtificial Metalloprotein Assemblies and MaterialsAkif Tezcan Universit of California San Diego
2:30 PMDirect Detection of Protons in Oxidized and Reduced Human Manganese Superoxide DismutaseGloria Borgstahl University of Nebraska Medical Center
3:00 PMBreak  
3:30 PMFixed Target Serial Crystallography at Diamond Light SourceGraeme Winter Diamond Light Source
4:00 PMGeometric and Electronic Structure of Organometallic Intermediates in Acetyl CoA SynthaseRiti Sarangi SLAC/SSRL
4:30 PMWrap-up  

 

Materials Science X-ray Diffraction Opportunites

There are exciting things happening for the SSRL scattering beamlines. We are in the process of building a new undulator beamline, BL17-2, to provide world-class scattering capabilities which will replace the science program at BL7-2. This new beam line, which should be ready for users a year from now, will have a 6 circle (psi C) diffractometer, analyzers and several 2D detectors, including a Eiger 4M and Eiger 2 500K. BL17-2 will have a focus spot of sub 20 microns in both directions with > 1 10^12 photons with the high resolution detector and 10^13 with a multilayer. We are organizing this workshop to explore various scientific applications that such a new beamline could enable. We look forward to sharing the design plans of this new beamline and discussing the new science that this will enable for our users.

  • Location:  Trinity Conference Room, Building 053/Room 1350
  • Organizers:  Apurva MehtaKevin Stone (SLAC/SSRL)
  • Invited Speakers: 
    • Gaurav (Gino) Giri, U Virginia
    • Joanne Stubbs, U Chicago
    • Stephen Wilson, UCSB
    • Badri Shyam, University of Dayton Research Institute
  • Program: ​
TimeSpeakerTopicInstitution
9:00 AMMichael ToneyBL17 Characteristics and OverviewSLAC
9:30 AMJoanne StubbsTBDUniv. of Chicago
10:00 AMYayoi TakamuraTBDUC Davis
10:30 AMBreak (Group Photo-meet in front of SUSB)  
11:00 AMGuarav GiriTBDUniv. of Virginia
11:30 AMStephen WilsonTBDUC Santa Barbara
12:00 PMLunch  
1:30 PMBadri ShyamTBDUniv. of Dayton Research Institute
2:00 PMHans-Georg SteinrükTBDSLAC
2:30 PMBreak  
2:50 PMDiana GamzinaTBDSLAC
3:20 PMKevin StoneBeamline Commissioning TimelineSLAC
3:45 PMPanel discussion/Q&A with beamline scientists  
4:30 PMAdjourn  

 

Ultrafast Electron Diffraction (UED) Workshop

The UED workshop will discuss developments in UED science and related ultrafast techniques. It will be an opertunity to discuss the latest developments in ultrafast material and chemical sciences, solicit feedback about the first UED user run, and inform future developements of the SLAC MeV UED instrument.

  • Location:  ROB Conference Rooms A/B/C/D, Building 48
  • Lead Organizer: Alex Reid
  • Organizers: Jie YangXiaozhe ShenMing-Fu LinMichael Kozina
  • Abstract: Ultrafast MeV Electron Diffraction is a powerful tool for exploring material and chemical dynamics at Angstrom lengthscales and femtosecond time scale. The SLAC MeV UED instrument offered its first open call for user experiments in January 2019. This workshop will focus on major questions in ultrafast science, and how time-resolved MeV UED can be an effective tool towards answers. The worshop will cover both material science (with emphasis on quantum materials) and gas/liquid-phase chemistry.
  • Program:
TimeTitle of TalkSpeakerInstitution
 Session Chair: Alex Reid (SLAC)  
1:00 PMUED Solid State UpdateXiaozhe ShenSLAC
1:15 PMTime Resolved Probing of Photo-induced Phase Transitions in Charge Density WavesNuh GedikMassachusetts Institute of Technology
1:40 PMTBDMingda LiMassachusetts Institute of Technology
2:05 PMTime-resolved probes of hydrodynamic behavior in quantum materialsMatteo MitranoUniversity of Illinois at Urbana–Champaign
2:30 PMBreak  
 Session Chair: Jie Yang (SLAC)  
3:00 PMUED Gas Phase UpdateMing-Fu LinSLAC
3:15 PMComparing structural and spectroscopic probes of excited state molecular dynamics: Relativistic ultrafast electron diffraction vs Time resolved photoelectron spectroscopy.Thomas WeinachtStony Brook University
3:40 PMExcited States Structure Determination with X-rays and ElectronsPeter WeberBrown University
4:05 PMLiquid Phase MeV-UED: Commissioning and First Results.Kathryn LedbetterStanford University
4:30 PMConclusion of Workshop  

 

 

Satellite Events

SLAC, Stanford and X The Moonshot Factory announce the 2019 Falling Walls Lab Stanford to be held at SLAC’s Kavli Auditorium in Building 51 on Tuesday, September 24, 3-5 pm. At this fun competition and networking event, you can pitch your great new idea or watch the competitors pitch theirs. Anyone within 10 years of Bachelors, 7 years of Masters or 5 years of PhD is eligible to compete. The winner will receive a trip to the final on November 9 in Berlin. To learn more or apply, visit  https://falling-walls.com/lab/apply